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KMID : 1161920150120010020
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Journal of Medicine and Life Science
2015 Volume.12 No. 1 p.20 ~ p.22
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Drug-induced cardiovascular disorders
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Lee Eun-Kyoung
Lee Jae-Chun
Han Hye-Jung
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Abstract
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Adverse drug reactions (ADRs) affecting cardiovascular system might be underestimated and underreported in clinical practice. Most common culprit drugs are anthracyclines, antipsychotics and cyclooxygenase (COX)-2 inhibitors. Anthracyclines may induce myocardial damage with oxidative stress, which is mostly irreversible. Type I ADRs are commonly encountered in antipsychotic use. Attention should be paid to the risk of sudden cardiac death related to some antipsychotics. COX inhibitors pharmacologically have antithrombotic activities. However, in COX2 selective inhibitors, myocardial infarction and stroke might be induced paradoxically.
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KEYWORD
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Adverse drug reaction, Cardiovascular system, Cardiovascular diseases
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